Skip to the reading [American Peptide Supply](/) Four chapters on the supply picture - [01 The change](/#the-change) - [02 The history](/#the-history) - [03 Who does what](/#who-does-what) - [04 Keeping care](/#keeping-care) A U.S. supply guide · Read on 27 October 2026 # The sources behind the shortage story FDA decisions, supply records and explanations of the rules, with a note on what each one tells you. ## A date is part of a source These are the sources behind the guide. For a past turning point, the FDA decision explains what changed. For today’s national supply question, the shortage database is the place to return. The two orders below cover semaglutide and tirzepatide injections. Later updates explain how the compounding rules changed afterward. A notice about one medicine or form doesn’t settle the status of another. The notes say what each source helps explain. They don’t decide what treatment fits you; that needs a personal care conversation. ![A delivery driver lifts plain unmarked cardboard cartons from the open back of a white van at a loading dock in early light.](/aps-calendar-3ef9e129bd73/edges-and-dates.webp) A delivery reaches one receiving door. FDA’s national supply finding answers a wider question, and keeps the date on which it was made. ## The public readings ### [FDA’s shortage and compounding timeline](https://www.fda.gov/drugs/drug-alerts-and-statements/fda-clarifies-policies-compounders-national-glp-1-supply-begins-stabilize) Semaglutide and tirzepatide shortage decisions, the 2025 wind-down dates and the 1 April 2026 policy update. U.S. Food and Drug Administration · Accessed 27 October 2026 ### [Declaratory Order: Resolution of Shortages of Semaglutide Injection Products](https://www.fda.gov/media/185526/download?attachment=) The 21 February 2025 semaglutide decision, including the separate 2022 Wegovy and Ozempic listings. U.S. Food and Drug Administration · Accessed 27 October 2026 ### [Declaratory Order: Resolution of Shortages of Tirzepatide Injection Products](https://www.fda.gov/media/184606/download?attachment=) The 19 December 2024 tirzepatide decision, replacing the October decision after another review. U.S. Food and Drug Administration · Accessed 27 October 2026 ### [Frequently Asked Questions about Drug Shortages](https://www.fda.gov/drugs/drug-shortages/frequently-asked-questions-about-drug-shortages) How a national shortage differs from trouble finding a medicine locally. U.S. Food and Drug Administration · Accessed 27 October 2026 ### [Compounding and the FDA: Questions and Answers](https://www.fda.gov/drugs/human-drug-compounding/compounding-and-fda-questions-and-answers) What compounding means, how oversight works and why compounded drugs are not approved generics. U.S. Food and Drug Administration · Accessed 27 October 2026 ### [Understanding the Risks of Compounded Drugs](https://www.fda.gov/drugs/human-drug-compounding/understanding-risks-compounded-drugs) How contamination or an incorrect amount of active ingredient can cause serious harm. U.S. Food and Drug Administration · Accessed 27 October 2026 ### [Information for Outsourcing Facilities](https://www.fda.gov/drugs/human-drug-compounding/information-outsourcing-facilities) The manufacturing, inspection and reporting duties of registered outsourcing facilities. U.S. Food and Drug Administration · Accessed 27 October 2026 ### [FDA alert about dosing errors with compounded injectable semaglutide](https://www.fda.gov/drugs/human-drug-compounding/fda-alerts-health-care-providers-compounders-and-patients-dosing-errors-associated-compounded) The July 2024 alert about reported dosing errors with compounded injectable semaglutide, some involving hospital care. U.S. Food and Drug Administration · Accessed 27 October 2026 ### [Compounding when Drugs are on FDA’s Drug Shortages List](https://www.fda.gov/drugs/human-drug-compounding/compounding-when-drugs-are-fdas-drug-shortages-list) Which copy restrictions change during shortages, and which other conditions remain. U.S. Food and Drug Administration · Accessed 27 October 2026 ### [Prescription Requirement Under Section 503A — guidance overview](https://www.fda.gov/regulatory-information/search-fda-guidance-documents/prescription-requirement-under-section-503a-federal-food-drug-and-cosmetic-act-guidance-industry) The introduction to FDA’s guidance on prescriptions for identified individual patients. U.S. Food and Drug Administration · Accessed 27 October 2026 ### [Prescription Requirement Under Section 503A — full guidance](https://www.fda.gov/media/97347/download) The full guidance on individual prescriptions and limited preparation ahead of them. U.S. Food and Drug Administration · Accessed 27 October 2026 ### [Drug Shortage Staff](https://www.fda.gov/drugs/drug-shortage-staff) How manufacturer reports help FDA keep shortage information up to date. U.S. Food and Drug Administration · Accessed 27 October 2026 ### [NLM Web Policies — medical information](https://www.nlm.nih.gov/web_policies.html) The difference between general medical information and advice about your own care. U.S. National Library of Medicine · Accessed 27 October 2026 ### [Drug Shortages — search and reporting routes](https://www.fda.gov/drugs/drug-safety-and-availability/drug-shortages) How to search for a medicine and report a possible shortage. U.S. Food and Drug Administration · Accessed 27 October 2026 ### [FDA Drug Shortages database](https://www.accessdata.fda.gov/scripts/drugshortages/) The national database: current shortages, resolved shortages and product discontinuations. U.S. Food and Drug Administration · Accessed 27 October 2026 ### [Questions and Answers: Outsourcing Facility Registration](https://www.fda.gov/drugs/human-drug-compounding/questions-and-answers-outsourcing-facility-registration) Why registering a facility does not prove compliance or approve its medicines. U.S. Food and Drug Administration · Accessed 27 October 2026 [Read how we approach the supply question](/about) We follow the supply calendar as a guide; we are neither a clinic nor a pharmacy, and we sell nothing. [References](/references) [About](/about) [Contact](/contact) © 2026 American Peptide Supply